Therapeutic hypothermia is also thought to potentially offer some renoprotection by reducing metabolic demand and oxygen consumption. In adults experiencing out-of-hospital cardiac arrests, use of therapeutic hypothermia has been associated with decreased neurologic morbidity and mortality [40]. However, the impact of hypothermia on renal function in severely asphyxiated neonates has not been prospectively studied. In a recent retrospective review of severely asphyxiated newborns treated with therapeutic hypothermia, Selewski et al. reported an AKI incidence of 38 %, somewhat lower than that reported in historical studies performed before therapeutic hypothermia became the standard care [8].
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